11C-radiolabeling of hallucinogenic psilocin, a potential radioligand for studying the role of serotonin receptors in psychotic symptom formation

1998 ◽  
Vol 41 (7) ◽  
pp. 585-594 ◽  
Author(s):  
S. Ametamey ◽  
F. X. Vollenweider ◽  
J. Patt ◽  
D. Bourquin ◽  
F. Hasler ◽  
...  
Keyword(s):  
Psychotic Symptom ◽  
Serotonin Receptors ◽  
Symptom Formation

Toll-like receptors 2 and 4 exert opposite effects on the contractile response induced by serotonin in mouse colon: role of serotonin receptors

2016 ◽  
Vol 101 (8) ◽  
pp. 1064-1074 ◽  
Author(s):  
R. Forcén ◽  
E. Latorre ◽  
J. Pardo ◽  
A. I. Alcalde ◽  
M. D. Murillo ◽  
...  
Keyword(s):  
Serotonin Receptors ◽  
Contractile Response ◽  
Toll Like Receptors ◽  
Mouse Colon

scholarly journals Serotonin Receptors – From Molecular Biology to Clinical Applications

2011 ◽  
pp. 15-25 ◽  
Author(s):  
M. PYTLIAK ◽  
V. VARGOVÁ ◽  
V. MECHÍROVÁ ◽  
M. FELŠÖCI
Keyword(s):  
Pulmonary Hypertension ◽  
Serotonin Receptors ◽  
Clinical Applications ◽  
Panic Disorders ◽  
The Past ◽  
Complex Processes ◽  
Selective Agents ◽  
Different Populations ◽  
Irritable Bowel

Serotonin (5-hydroxytryptamine) is an ubiquitary monoamine acting as one of the neurotransmitters at synapses of nerve cells. Serotonin acts through several receptor types and subtypes. The profusion of 5-HT receptors should eventually allow a better understanding of the different and complex processes in which serotonin is involved. Its role is expected in the etiology of several diseases, including depression, schizophrenia, anxiety and panic disorders, migraine, hypertension, pulmonary hypertension, eating disorders, vomiting and irritable bowel syndromes. In the past 20 years, seven distinct families of 5-HT receptors have been identified and various subpopulations have been described for several of them. Increasing number of 5-HT receptors has made it difficult to unravel the role of 5-HT receptor subpopulations due to the lack of suitable selective agents. The present review describes the different populations and nomenclature of recently discovered 5-HT receptors and their pharmacological relevance.

scholarly journals Role of some types of serotonin receptors in murine hypophyseal-testicular complex activation induced by the presence of a female

2003 ◽  
Vol 49 (6) ◽  
pp. 53-56
Author(s):  
T. G. Amstislavskaya ◽  
N. K. Popova
Keyword(s):  
Serotonin Receptors ◽  
Receptor Agonist ◽  
Serotonin Receptor ◽  
Receptive Female ◽  
Plasma Testosterone ◽  
Blood Levels ◽  
Inhibitory Effects ◽  
Sexual Activation ◽  
Different Types

Placement of a sexually receptive female mouse behind a partition that prevents physical contacts, but permits it to see and smell caused an increase in the blood levels of testosterone in male mice. The selective 5-HTIA-serotonin receptor agonist 08-OH- DPAT (0.1 mg/kg) and the mixed 5-HTIA/IB agonist eltoprazine, 3.0 and 10.0 mg/kg, blocked the activating effect of female exposure on the male pituitary-testicular system. The 5-HT/-receptor agonist p-MPPI (0.2 mg/kg) prevented the inhibitory effects of 8-OH-DPATand eltoprazine. The 5-HT/B-receptor agonist CGS- 12066A (1.0 and 2.0 mg/kg) exerted no effect while the mixed 5-HTIB/2C-receptor agonist TFMPP (5.2 mg/kg) inhibited a female-induced increase in the levels of male blood testosterone. The 5-HT/-receptor agonist keranserin (1.0 and 2.0 mg/kg) prevented a female-induced increase in the levels of testosterone. The 5-HT3-receptor agonist ondansetron (0.05 and 0.1 mg/kg) elevated the baseline level of plasma testosterone, but blocked receptive female-induced activation of the male hypothalamic-pituitary-testicular system (HPTS). It is concluded that 5-HTIA-receptors are involved in the control of male sexual activation. At the same time different types and even subtypes of the same type of 5-HT-receptors produce varying inhibitory and activating effects on the receptive female-induced activation of HPTS. Blocking of the female-induced activation of HPTS seems to be realized by involving 5-HTu- and 5-HT2C-receptors and its activation occurs with the participation of 5-HT^- and 5- HT3-receptors.

Role of alfalfa mosaic virus coat protein gene in symptom formation

Virology ◽  
1991 ◽  
Vol 181 (2) ◽  
pp. 687-693 ◽  
Author(s):  
Lyda Neeleman ◽  
Antoinette C. Van Der Kuyl ◽  
John F. Bol
Keyword(s):  
Coat Protein ◽  
Mosaic Virus ◽  
Coat Protein Gene ◽  
Protein Gene ◽  
Alfalfa Mosaic Virus ◽  
Virus Coat Protein ◽  
Virus Coat ◽  
Symptom Formation

28 THE REGULATION OF NEURONAL OUTGROWTH AND RETRACTION BY SEROTONIN RECEPTORS 5-HT4a AND 5-HT7: THE ROLE OF LIM KINASE 1.

2006 ◽  
Vol 54 (2) ◽  
pp. S348.2-S348
Author(s):  
A. Krbanjevic ◽  
G. Liu ◽  
J. Profirovic ◽  
T. Voyno-Yasenetskaya
Keyword(s):  
Serotonin Receptors ◽  
Lim Kinase ◽  
Lim Kinase 1 ◽  
Neuronal Outgrowth

Prostaglandins mediate skeletal muscle arteriole dilation in hyperdynamic bacteremia

1990 ◽  
Vol 259 (3) ◽  
pp. H728-H734
Author(s):  
H. G. Cryer ◽  
R. N. Garrison ◽  
P. D. Harris ◽  
B. H. Greenwald ◽  
N. L. Alsip
Keyword(s):  
Skeletal Muscle ◽  
Topical Application ◽  
Serotonin Receptors ◽  
Cremaster Muscle ◽  
Synthesis Inhibitor ◽  
E Coli ◽  
Decerebrate Rat ◽  
Prostaglandin Synthesis Inhibitor ◽  
Baseline Values

Live Escherichia coli bacteremia during the high cardiac output (hyperdynamic) phase of sepsis causes constriction of large arterioles but dilation of small arterioles in skeletal muscle. This study examines the role of dilator prostaglandins, serotonin, and histamine in these differential microvascular responses in the decerebrate rat that avoids the effects of drug anesthesia. Topical application of meclofenamate, a prostaglandin synthesis inhibitor, to the cremaster muscle 60 min after induction of E. coli bacteremia enhanced the constriction of large arterioles from 20 +/- 8 to 46 +/- 9% less than baseline and blunted the dilation of small arterioles from 39 +/- 9 to 17 +/- 7% above baseline values in the cremaster microcirculation. Induction of E. coli bacteremia after pretreatment of the cremaster with meclofenamate constricted large arterioles to 40 +/- 4% less than baseline and small arterioles to 31 +/- 4% less than baseline. This indicates that prostaglandins initiate small arteriole dilation in response to E. coli, but some other dilator factor is activated by prostaglandins to maintain small arteriole dilation during E. coli bacteremia. Topical application of cyproheptadine, an antagonist of both histamine and serotonin receptors, to the cremaster muscle did not alter the E. coli-induced constriction of large arterioles or the dilation of small arterioles in the cremaster microcirculation.

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